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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2747 | Endothall | Others | |
Endothall is an effective protein phosphatase 2A (PP2A) inhibitor, exerting inhibitory effects on both PP2A and PP1, with IC50 values of 90 nM and 5 µM, respectively. It exhibits anticancer activity, making it suitable f... | |||
T9744 | MP07-66 | Phosphatase | |
MP07-66 is a novel FTY720-analog devoid of immunosuppressive effects leads to the reactivation of PP2A, which in turn triggers apoptosis of CLL cells. | |||
TN1305 | Ethoxysanguinarine | 6-Ethoxydihydrosanguinarine | Apoptosis , AChR |
Ethoxysanguinarine (6-Ethoxydihydrosanguinarine) shows human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBuChE) inhibitory activity, with IC50 values of 0.83 +/- 0.04 microM and 4.20 +/-... | |||
T35528 | TD52 | Apoptosis , Phosphatase , Akt | |
TD52 is an orally active inhibitor of cancerous inhibitor of PP2A (CIP2A). TD52 is an Erlotinib derivative and indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. | |||
T60688 | MKI-1 | MASTL Kinase Inhibitor-1 | Others |
MKI-1 (MASTL Kinase Inhibitor-1) is an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like, IC50= 9.9 μM). MKI-1 exerts radiosensitizer and antitumor activities through PP2A activation in breast cance... | |||
T4449 | LB100 | LB-100,LB 100 | Phosphatase |
LB100 (LB-100) is a water soluble protein phosphatase 2A (PP2A) inhibitor. | |||
T5182 | AMZ30 | Others | |
AMZ30 is a selective inhibitor of PME-1 (IC50: 600 nM). It also reduces the demethylated form of PP2A in living cells. | |||
T2068 | (Rac)-LB-100 | Phosphatase | |
LB-100, a novel Protein Phosphatase 2A (PP2A) inhibitor, sensitizes malignant meningioma cells to the therapeutic effects of radiation | |||
T5891 | D-ERYTHRO-SPHINGOSINE | trans-4-Sphingenine,erythro-C18-Sphingosine,Erythrosphingosine | Phosphatase , Endogenous Metabolite , PKC |
D-erythro-Sphingosine (trans-4-Sphingenine) is a protein kinase C (PKC) inhibitor. D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator | |||
T35528L | TD52 dihydrochloride | TD52 dihydrochloride(1798328-24-1 Free base),TD52 2HCl | Others |
TD52 dihydrochloride (TD52 2HCl), a derivative of Erlotinib, is a potent and orally active inhibitor of protein phosphatase 2A (CIP2A). It exhibits strong anti-cancer properties by regulating the CIP2A/PP2A/p-Akt signali... | |||
T26164 | Rubratoxin A | ||
Rubratoxin A is a classical mycotoxin used as a PP2A-specific inhibitor. | |||
T63259 | PP2A Cancerous-IN-1 | ||
PP2A Cancerous-IN-1 is a potent inhibitor of CIP2A (Cancerous inhibitor of PP2A) and p-Akt that exhibits potent anti-proliferative effects. | |||
T35806 | N-Stearoylsphingosine | C(18:0)/C(18:1),Cer(d18:1/18:0),C18 Ceramide (d18:1/18:0),C18 Ceramide | Phosphatase |
N-Stearoylsphingosine is an amide compound widely found in eukaryotic organisms that enhances protein phosphatase 2A (PP2A) activity by interfering with the binding of PP2A to PP2A inhibitor 2, leading to dephosphorylati... | |||
T14859 | Calyculin A | (-)-Calyculin A | Others |
Calyculin A is a potent and cell-permeable inhibitor of protein phosphatase 1 (PP1; IC50s: 2 nM). It also is a protein phosphatase 2A (PP2A) inhibitor (IC50s: 0.5-1 nM). | |||
T83530 | LB-100 | ||
(Rac)-LB-100 is the racemic form of the compound LB-100, which functions as an inhibitor of protein phosphatase 2A (PP2A) [1]. | |||
T13095 | Tautomycin | Others | |
Tautomycin is a potent and specific protein phosphatases 1 and 2A inhibitor (Kiapp of 0.16 nM and 0.4 nM for PP1 and PP2A, respectively), and is an antifungal antibiotic isolated from the bacterium Streptomyces verticill... | |||
TP2054 | Calcineurin Autoinhibitory Peptide | ||
Selective inhibitor of Ca2+-calmodulin-dependent protein phosphatase (calcineurin) (IC50 ~ 10 μM). Does not inhibit PP1, PP2A or CaM kinase II (IC50 > 100 mM). | |||
T16381 | Okadaic acid | Others | |
Okadaic acid is a non-comepetitive, selective and reversible serine/threonine-specific protein phosphatases 1 (PP1), PP2A, and PP3 inhibitor (IC50s: 10-15 nM, 0.5 nM, and 4 nM, respectively). Okadaic acid is extracted fr... | |||
T37055 | Cytostatin | ||
Cytostatin is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 μg/ml, respectively) and B16 cel... | |||
T68458 | Fostriecin (free base) | ||
Fostriecin (free base) is an inhibitor of the serine/threonine protein phosphatases 2A (PP2A) and 4 (PP4) (IC50s = 3.2 and 3 nM, respectively). It less effectively inhibits topoisomerase II and PP1 (IC50s = 40 and 131 μM... |